Predicting allograft tolerance

iPSC-MSCs and islet allograft tolerance

The immunosuppressive effect and low immunogenicity of mesenchymal stem cells (MSCs) make them ideal candidates for immunosuppressive strategies. Adult MSCs have been applied widely in organ transplantation. However, their limited accessibility limits their application in the clinic. Furthermore, successive passages slow the proliferation rate, reduce the multipotency and lower the immunosuppre...

Acquired tolerance, allograft "acceptance," and immune suppression.

Early tolerance in pediatric liver allograft recipients.

The authors report on six pediatric liver transplant recipients for whom allograft tolerance occurred shortly after transplantation (ie, less than 1.5 years). All the patients had associated life-threatening viral complications. They are currently immunocompetent. The tolerant state may be related to the development of a TH2 cytokine pattern.

Meniscal Allograft Transplantation: Factors Predicting Failure

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Factors Predicting Meniscal Allograft Transplantation Failure

BACKGROUND Meniscal allograft transplantation (MAT) is performed to improve symptoms and function in patients with a meniscal-deficient compartment of the knee. Numerous studies have shown a consistent improvement in patient-reported outcomes, but high failure rates have been reported by some studies. The typical patients undergoing MAT often have multiple other pathologies that require treatme...